Tesis doctoral de Veronica Ortiz De Elguea Flecha
The research work described in this thesis is focused on the development of new methods for the synthesis of quinoline and coumarin scaffolds using palladium-catalyzed alkenylation reactions for the formation of carbon-carbon bonds.The intramolecular mizoroki-heck reaction has been extended to the synthesis of 2-heteroaryl-4-methylenetetrahydroquinolines, and its competition with direct arylation reaction has been studied. The intramolecular fujiwara-moritani reaction has been disclosed as an attractive alternative to the mizoroki-heck reaction for the construction of polysubstituted quinolines, quinolones and coumarins through pd(ii)-catalyzed cyclizations. An efficient methodology for the construction of 4-substituted 3-alkenylquinolin-2-one scaffolds has been developed, involving intermolecular pd(ii)-alkenylation reactions.
Datos académicos de la tesis doctoral «Ready access to substituted quinoline and coumarin scaffolds via palladium-catalyzed alkenylation reactions«
- Título de la tesis: Ready access to substituted quinoline and coumarin scaffolds via palladium-catalyzed alkenylation reactions
- Autor: Veronica Ortiz De Elguea Flecha
- Universidad: País vasco/euskal herriko unibertsitatea
- Fecha de lectura de la tesis: 16/12/2014
Dirección y tribunal
- Director de la tesis
- Nuria Sotomayor Anduiza
- Tribunal
- Presidente del tribunal: sergio Castillon miranda
- amelia pilar Grases dos santos silva rauter (vocal)
- rosa Lopez alvarez (vocal)
- roser Pleixats rovira (vocal)