Tesis doctoral de Ruben Agudo Torres
1 summary rna virus populations are complex distributions of closely related but non-identical variant genomes termed quasispecies. The large heterogeneity in quasispecies is due to the low fidelity of viral rna polymerases and the lack of error-repair activities during replication. studies on genome replication with high error rates predict the existence of an error threshold above which the maintenance of the genetic information would not be possible. The violation of this threshold by increasing the error rate is termed entry into error catastrophe. This fact opens interesting possibilities for the design of a new antiviral compounds with mutagenic properties. the main objective of this ph. D. Thesis is to define and characterize the viral determinants that play a role either in sensitivity or in resistance of viruses to mutagenic agents, in the context of the quasispecies dynamics.
Datos académicos de la tesis doctoral «Caracterización de las proteínas del virus de la fiebre aftosa implicada en respuesta a mutagénesis letal por análogos de nucleótido.«
- Título de la tesis: Caracterización de las proteínas del virus de la fiebre aftosa implicada en respuesta a mutagénesis letal por análogos de nucleótido.
- Autor: Ruben Agudo Torres
- Universidad: Autónoma de Madrid
- Fecha de lectura de la tesis: 19/06/2009
Dirección y tribunal
- Director de la tesis
- Esteban Domingo Solans
- Tribunal
- Presidente del tribunal: jose Fernandez piqueras
- ester Lázaro (vocal)
- Miguel ángel Martínez de la sierra (vocal)
- nuria Verdaguer massana (vocal)