Tesis doctoral de Marta Fernández Galilea
α-lipoic acid (5-(1,2-dithiolan-3-yl)-pentanoic acid) is a natural occurring compound which possesses antioxidant properties. Moreover, anti-obesity properties in both rodents and humans have been attributed to α-lipoic acid being adipose tissue a target for this compound. In this context, the present study has demonstrated the ability of α-la to modulate lipid metabolism in both murine and human white adipocytes. Thus, α-la: 1) inhibits fatty acids uptake (through cd36 downregulation); 2) reduces fatty acids esterification into triglycerides (through dgat1 reduction); 3) decreases de novo lipogenesis (induced by inhibition of fas, scd1 and acc mediated by ampk activation); 4) stimulates lipolysis (mainly mediated by the phosphorylation of hsl through camp-mediated activation of pka, probably through the inhibition of adpla and pge2; 5) increases fatty acid oxidation machinery (cpt1 and acox) in white adipocytes; 6) promotes mitochondrial biogenesis by the activation of pgc-1α mediated by sirt1 and ampk activation; and 7) induces a brown-like remodelling in white subcutaneous adipocytes from overweight/obese subjects. taking together all of these facts suggest that α-la remodels adipocyte metabolism towards oxidation rather than storage, and this could contribute to the anti-obesity properties of α-la.
Datos académicos de la tesis doctoral «Effects of alfa-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved«
- Título de la tesis: Effects of alfa-lipoic acid on lipid metabolism and mitochondrial biogenesis in adipocytes: study of the molecular mechanisms involved
- Autor: Marta Fernández Galilea
- Universidad: Navarra
- Fecha de lectura de la tesis: 18/12/2013
Dirección y tribunal
- Director de la tesis
- María Jesús Moreno Aliaga
- Tribunal
- Presidente del tribunal: María del puy Portillo baquedano
- ricardo Rueda cabrera (vocal)
- cedric Moro (vocal)
- María José Iraburu elizalde (vocal)