Tesis doctoral de Montserrat Vaqué Marqués
The influence of nutrition on our daily lives has been one of the main driving forces behind the development of new genomic technologies which are used, among other applications, to improve the processing, the safety, the quality and the health-derived benefits of food. Moreover it is now the age of nutrigenomics (i.E. A science whose goal is to understand, at the molecular level, how nutrients improve health conditions and prevent diseases) and nutrigenetics (i.E. A science whose goal is to understand how the genetic makeup of individuals coordinates their response to diet). Both sciences have developed out of recent research that has shown: (a) the influence of nutrition on gene expression; and (b) the significant effect of genetic variation on food intake, metabolic response to food, individual nutrient requirements and the efficacy of disease-protective dietary factors. Therefore, foods can be developed to be specific to individual human genotypes, can benefit health and can enhance normal physiological processes. For this reason, it has been suggested that food may become the pharmaceutical products of the future. In order to achieve this goal, in silico approaches can be useful for analyzing the intermolecular interactions between nutrients and proteins or genes and how these interactions modulate the corresponding target function. Despite recent contributions in this field, computational methods developed for molecular design and simulation (e.G. Pharmacophore generation and protein-ligand docking) which are routinely applied to develop drugs in the pharmaceutical industry are still not frequently used in nutrigenomics or nutrigenetics. From our point of view, the in silico tools and classical in vivo and in vitro methods must be applied together on natural products in order to study their efficacy in the development of functional foods (i.E. Food that has health benefits beyond the traditional nutrients it contains). The reason is that these computational me
Datos académicos de la tesis doctoral «In silico studies of the effect of phenolic compounds from grape seed extracts on the activity of phosphoinositide 3-kinase (pi3k) and the farnesoid x receptor (fxr)«
- Título de la tesis: In silico studies of the effect of phenolic compounds from grape seed extracts on the activity of phosphoinositide 3-kinase (pi3k) and the farnesoid x receptor (fxr)
- Autor: Montserrat Vaqué Marqués
- Universidad: Rovira i virgili
- Fecha de lectura de la tesis: 09/01/2008
Dirección y tribunal
- Director de la tesis
- Gerard Pujadas Anguiano
- Tribunal
- Presidente del tribunal: francesc xavier Avilés puigvert
- francesc xavier Remesar betlloch (vocal)
- Santiago Garcia vallvé (vocal)
- jordi Bujons vil?s (vocal)