Tesis doctoral de Gemma Montagut Pino
A grape-seed derived procyanidins extract (gspe) was reported to mimic some of the physiological effects of insulin. However, gspe showed some divergences when compared to insulin action, which suggests that procyanidins could be useful on a state of impaired insulin action. Therefore, the main purpose of this thesis was to understand how dietary procyanidins modulate glucose metabolism, mainly in adipose tissue and under an insulin resistant condition. results show that a treatment of 25 mg gspe/kg bw for 30 days on cafeteria-diet-fed rats has a positive effect in improving some insulin resistance parameters and that white adipose tissue is also a clear target for procyanidins. Cell culture studies showed the ability of procyanidins for activating the insulin receptor and its ability for activating proteins kinases involved in the insulin signalling pathway. The gspe study was completed showing that oligomeric structures of gspe can reproduce the total gspe effects.
Datos académicos de la tesis doctoral «Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells«
- Título de la tesis: Procyanidin effects on an impaired glucose metabolism: a further insight into procyanidin signalling in adipose cells
- Autor: Gemma Montagut Pino
- Universidad: Rovira i virgili
- Fecha de lectura de la tesis: 10/07/2009
Dirección y tribunal
- Director de la tesis
- Anna Ardévol Grau
- Tribunal
- Presidente del tribunal: Francisco abraham Tomas barberan
- José Antonio Fernández lópez (vocal)
- francesc Vidal marsal (vocal)
- silvia Mora (vocal)