Tesis doctoral de José María Moreno Navarrete
To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration was significantly decreased in subjects with altered glucose tolerance (agt) and associated negatively with obesity-related metabolic disturbances. The snps-induced aminoacidic changes in lactoferrin n-terminus region were associated with a low atherogenic lipid profile. Lactoferrin production in neutrophils decreased significatively in aging, chronic low-grade inflammation and type 2 diabetes. In vitro, lactoferrin increased insulin signaling pathway, even under insulin resistance conditions and displayed dual effects on adipogenesis (antiadipogenic in 3t3-l1 and adipogenic in human adipocytes). In conclusion, lactoferrin might play a potential protective role against insulin resistance and obesity related metabolic disturbances.
Datos académicos de la tesis doctoral «Immunomodulation and metabolism: possible role of lactoferrin«
- Título de la tesis: Immunomodulation and metabolism: possible role of lactoferrin
- Autor: José María Moreno Navarrete
- Universidad: Girona
- Fecha de lectura de la tesis: 20/06/2011
Dirección y tribunal
- Director de la tesis
- real Lemos Fernández
- Tribunal
- Presidente del tribunal: Antonio Zorzano olarte
- carmen Carretero romay (vocal)
- joan Vendrell ortega (vocal)
- María Vilanova brugués (vocal)