Tesis doctoral de Marta Dobarro Bugarín
Alzheimer¿s disease (ad) is the most common neurodegenerative disorder. Ad is defined by progressive memory loss and cognitive impairments and at the molecular level by the presence of neurofibrillary tangles, composed of hyperphosphorylated tau fibrils, and aí¢-containing amyloid plaques. antihypertensive treatments have been associated with lower incidence of clinically diagnosed ad and better cognitive function, and it has been tested whether some antihypertensive drugs might influence ad through mechanisms independent of blood pressure-lowering activity. Propranolol, a í¢-adrenergic antagonist that is commonly used in the treatment of hypertension, shown experimentally to reverse cognitive deficits associated to stress and decrease of aí¢ levels in vitro. in this work, we study the effect of propranolol in three animal models representing the three main groups of risk factors associated with the development of ad (age, genetics and environmental factors). After chronic treatment with propranolol at a lower dose than that used as antihypertensive (5 mg/kg), we evaluated the cognitive status of animals and different markers of ad in the hippocampus. in all cases, propranolol was able to reverse the increased levels of aí¢ and hyperphosphorylated tau. These effects may contribute to cognitive enhancement found in the three experimental models. In conclusion, propranolol seems to exert a protective role against disease neuropathology, making it a potential candidate for the treatment of ad.
Datos académicos de la tesis doctoral «Efectos del propanolol sobre deterioro cognitivo y las patologías amiloide y tau en distintos modelos experimentales de enfermedad de alzheimer«
- Título de la tesis: Efectos del propanolol sobre deterioro cognitivo y las patologías amiloide y tau en distintos modelos experimentales de enfermedad de alzheimer
- Autor: Marta Dobarro Bugarín
- Universidad: Navarra
- Fecha de lectura de la tesis: 24/10/2012
Dirección y tribunal
- Director de la tesis
- María Javier Ramirez Gil
- Tribunal
- Presidente del tribunal: alfredo Martínez ramírez
- julen Oyarzabal santamarina (vocal)
- mónica García alloza (vocal)
- ángel Cedazo minguez (vocal)