Tesis doctoral de Ruth Arís Sánchez
A cardiac computational model is a relevant tool that can give biomedical researchers an additional source of information to understand how the heart works. Numerical models can help to interpret experimental data and provide information about cardiac mechanisms that can not be determined accurately by classical clinical devices. in this thesis, high performance computing (hpc) techniques are used to build a cardiac computational tool, which is capable of running in parallel in thousands of processors, allowing high fidelity simulations on fine meshes. To simulate the pumping heart, an explicit coupling scheme between the three-dimensional electrophysiological equations and the solid mechanics formulation is used, solving the governing equations with finite element methods. Also, data assimilation techniques are implemented for the effective estimation of some relevant electrophysiological parameters, which is a crucial step towards the patient-sensitive cardiac model. The data assimilation techniques are assessed on synthetic data generated by the model. Finally, the computational code is applied to simulate real physical problems. The electromechanical propagation in a rabbit geometry is studied to test the sensitivity of the framework to input variations. Particularly, the computational tool is used to assess the influence of the fiber field in the contraction of the tissue. to develop a cardiac simulation useful for clinical purposes, the integrative model requires combining computational mechanics and image processing techniques via data assimilation methods. Coupled with the most advanced image processing analysis, the framework can be the base of theoretical studies into the mechanisms of cardiac pathologies. It can help surgery planning and cardiac modeling, such as the prediction of the impact of pharmacological compounds on the heart¿s rhythm or to improve the knowledge of drug study, giving medical researchers additional hints to understand the heart. This realization is only possible in a multi-disciplinary team, where specialized groups join forces in their respective disciplines: cardiologists, image researchers, bio-engineers and computational scientists. The present cardiac computational model is one further step towards the creation of a virtual lab.
Datos académicos de la tesis doctoral «Electromechanical large scale computational models of the ventricular myocardium«
- Título de la tesis: Electromechanical large scale computational models of the ventricular myocardium
- Autor: Ruth Arís Sánchez
- Universidad: Politécnica de catalunya
- Fecha de lectura de la tesis: 06/11/2014
Dirección y tribunal
- Director de la tesis
- María no Vázquez
- Tribunal
- Presidente del tribunal: pablo Lamata de la orden
- radomir Chabiniok (vocal)
- (vocal)
- (vocal)