Tesis doctoral de Marta Pérez Garay
This work shows that genes that codifying for the enzymes beta-galactoside alpha-2,3-sialyltransferase 3 (st3gal iii), and in a lower extent beta-galactoside alpha-2,3-sialyltransferase 4 (st3gal iv) , are directly implicated in key steps of tumour progression such as adhesion, migration and metastasis formation in the pancreatic adenocarcinoma cell lines capan-1 and mdapanc-28. Moreover, reactive oxygen species (ros) generated in those cell lines during cell proliferation-differentiation processes or by external oxidant stimuli, play a role in the control of st3gal iii and slex levels and in the acquisition of a more aggressive phenotype. And, together with the pro-adhesive role of e-selectin for circulating cells, this work uncovers se-selectin dependent migration and vegf secretion through a slex depending mechanism, supporting additional pro-metastatic effects for se-selectin-slex interaction.
Datos académicos de la tesis doctoral «Role of alpha 2,3-sialyltransferases st3gal iii and st3gal iv in pancreatic ductal adenocarcinoma«
- Título de la tesis: Role of alpha 2,3-sialyltransferases st3gal iii and st3gal iv in pancreatic ductal adenocarcinoma
- Autor: Marta Pérez Garay
- Universidad: Girona
- Fecha de lectura de la tesis: 07/02/2011
Dirección y tribunal
- Director de la tesis
- Rosa Peracaula Miró
- Tribunal
- Presidente del tribunal: pauline Rudd
- joan Figueras felip (vocal)
- enrique Querol murillo (vocal)
- Fernando Vidal vanaclocha (vocal)