Tesis doctoral de Ismail Abbas
Clinical trials are frequently very expensive and can last quite long. an error in the design of a clinical trial can imply the impossibility of confirming the hypothesis because of the fact results are lacking in statistical significance. This will mean to incur losses in resources and a delay in the introduction of the new pharmaceutical product into the market. in this thesis the clinical trial design is conceived as an economic optimisation problem. The concrete optimisation criterion might depend on the approach and the decision context. From the market point of view that seeks maximising benefits, clinical trials can be seen as an investment with relatively predictable costs but a much more uncertain future benefits. objectives and hypothesis of this thesis the main objective of this work is analysing and developing simulation models for the optimisation of clinical trial design. We have thus developed different computer-assisted stochastic models structures which allow conveniently to represent the clinical trial and simulate the results with alternative designs and hypothesis before carrying it out. The ultimate goal is determining which design optimises cost and clinical trial duration, by analysing hypothetical results before they are actually put into practice. the hypothesis wanted to be proved is that the development and application of the proposed simulation models allow more efficiently achieve the objectives formulated in a clinical trial, i.E. To obtain the sought results with a given success probability -what, as far as new pharmaceutical products is concerned, is a necessary condition before their commercialisation- with optimal cost and time span. method the general conceptual model to optimise a clinical trial we proposes in this thesis consists in two sub-models: a recruitment of patients and treatment assignment sub-model and a follow-up sub-model, which describes the evolution of the clinical trial
Datos académicos de la tesis doctoral «Integracion de los modelos de simulacion en el diseño de los ensayos clinicos«
- Título de la tesis: Integracion de los modelos de simulacion en el diseño de los ensayos clinicos
- Autor: Ismail Abbas
- Universidad: Politécnica de catalunya
- Fecha de lectura de la tesis: 26/04/2004
Dirección y tribunal
- Director de la tesis
- José Casanovas García
- Tribunal
- Presidente del tribunal: jaume Barceló bugeda
- jaume Canela soler (vocal)
- Fernando Antoñanzas villar (vocal)
- jordi Ocaña rebull (vocal)