Tesis doctoral de Meritxell Martinez Palau
The development of new biodegradable polymers is a subject of great interest due to their potential applications as both commodity and speciality materials. Most of the commercially available biodegradable polymer devices are polyesters due to their labile ester groups. For example, it should be pointed out the homopolymer and copolymers of glycolide which are mainly used in the biomedical field since their degradation products can be metabolizable by the human organism. The indicated copolymers are usually prepared by ring opening polymerization of glycolide and appropriate cyclic copolymers, and consequently have a random microstructure that hinders their crystallization. The synthesis and characterization of two alternating copolymers of glycolic acid and w-hydroxy acids, named poly[4-hydroxybutyric acid-alt-glycolic acid] and poly[glycolic acid-alt-6-hydroxyhexanoic acid], were studied in this thesis. A new synthetic method based on a thermal polycondensation with formation of a metal salt as a driving force has been developed. The new procedure and allows to obtain a highly porous material once the salt has been removed by washing with polar solvents. all the products obtained have been identified by means of nuclear magnetic resonance and infrared spectroscopy. Furthermore, the kinetics of the thermal polycondensation reaction and the thermal properties of the final products have been studied employing differential scanning calorimetry and thermogravimetric analysis. it is generally accepted that the macroscopic properties of polymers are governed by their microscopic morphology. For this reason, crystallization has been studied by using different techniques such as differential scanning calorimetry, optical microscopy and simultaneous time-resolved small angle xray scattering (saxs) and wide angle x-ray diffraction (waxd). The structure of the new synthesized polymers has also been studied by means of x-ray diffraction and electronic microscopy. biocompati
Datos académicos de la tesis doctoral «Sintesis, estructura y aplicaciones de poliesteres secuenciales derivados de acido glicolico y w-hidroxiacidos«
- Título de la tesis: Sintesis, estructura y aplicaciones de poliesteres secuenciales derivados de acido glicolico y w-hidroxiacidos
- Autor: Meritxell Martinez Palau
- Universidad: Politécnica de catalunya
- Fecha de lectura de la tesis: 16/04/2008
Dirección y tribunal
- Director de la tesis
- Jorge Puiggalí Bellalta
- Tribunal
- Presidente del tribunal: Juan Antonio Subirana torrent
- Francisco Lopez calahorra (vocal)
- goran Ungar (vocal)
- José María Salla tarragó (vocal)