Tesis doctoral de Gunes Gundem
Cancer is a complex disease that is the result of different types of genetic and epigenetic alterations. To gain a complete view of the tumorigenic process it is crucial to bring together complementary data sources. In this thesis, i describe intogen, an integrative framework that collects, analyzes and merges together different high-throughput functional genomic data. It provides data from many different types of cancers and also enables the interpretation of genome-wide data sets in the context of other studies and other cancer types. Since it is updatable and extendable, it also provides a framework upon which a system for the analysis of new types of oncogenomics data can be built. In addition to intogen, i propose a methodology based on sample-level enrichment analysis. This approach can be used to detect clinically relevant patient subgroups in intogen cancer data sets.
Datos académicos de la tesis doctoral «Computational study of cancer«
- Título de la tesis: Computational study of cancer
- Autor: Gunes Gundem
- Universidad: Pompeu fabra
- Fecha de lectura de la tesis: 29/09/2011
Dirección y tribunal
- Director de la tesis
- Nuria Lopez Bigas
- Tribunal
- Presidente del tribunal: Francisco xavier Real arribas
- migel angel Pujana genestar (vocal)
- (vocal)
- (vocal)