Computational study of cancer

Tesis doctoral de Gunes Gundem

Cancer is a complex disease that is the result of different types of genetic and epigenetic alterations. To gain a complete view of the tumorigenic process it is crucial to bring together complementary data sources. In this thesis, i describe intogen, an integrative framework that collects, analyzes and merges together different high-throughput functional genomic data. It provides data from many different types of cancers and also enables the interpretation of genome-wide data sets in the context of other studies and other cancer types. Since it is updatable and extendable, it also provides a framework upon which a system for the analysis of new types of oncogenomics data can be built. In addition to intogen, i propose a methodology based on sample-level enrichment analysis. This approach can be used to detect clinically relevant patient subgroups in intogen cancer data sets.

 

Datos académicos de la tesis doctoral «Computational study of cancer«

  • Título de la tesis:  Computational study of cancer
  • Autor:  Gunes Gundem
  • Universidad:  Pompeu fabra
  • Fecha de lectura de la tesis:  29/09/2011

 

Dirección y tribunal

  • Director de la tesis
    • Nuria Lopez Bigas
  • Tribunal
    • Presidente del tribunal: Francisco xavier Real arribas
    • migel angel Pujana genestar (vocal)
    • (vocal)
    • (vocal)

 

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