Tesis doctoral de Angel Luis Huidobro Peral
The discovery of new medicines has signified a breakthrough in the improvement of human health and quality of life. In the decision making processes along the way, risk/benefit assessments are always involved, making the pharmaceutical analysis crucial. In recent years there has been an increasing activity in pharmaceutical research leading to even more sophisticated and complicated samples to be analysed, requiring the development of new analytical strategies to meet the demands of industry. chromatographic sciences and pharmaceutical analysis are closely related research fields, continually posing new challenges for each other. fast, robust, selective methods for routine analysis in quality control do not seem to be the only requirements to be fulfilled nowadays. Chromatography is called upon to play a decisive role for many other steps, such as impurity profiling, the characterisation of excipients and the elucidation of degradation products, in order to achieve higher quality products. All these processes need to be assisted by more exhaustive separations. Therefore, chromatographers, as demonstrated in this memory, are needed to provide part of the key to the solution for pharmaceutical development. this thesis is concerned with different issues related to pharmaceutics, which emerged from our collaborations with pharmaceutical companies. The thesis deals with real new problems. Here is described how new approaches, in terms of analytical methodology, can still be innovative in practical applications. Efficient analytical methods have been developed, including separation techniques, for instance, hplc, ce, spe and 2d-lc, complemented by different elucidation techniques, such as mass spectrometry and nuclear magnetic resonance.
Datos académicos de la tesis doctoral «Innovative pharmaceutical analysis: new tools and approaches«
- Título de la tesis: Innovative pharmaceutical analysis: new tools and approaches
- Autor: Angel Luis Huidobro Peral
- Universidad: San pablo-ceu
- Fecha de lectura de la tesis: 16/12/2008
Dirección y tribunal
- Director de la tesis
- María Del Coral Barbas Arribas
- Tribunal
- Presidente del tribunal: jose Barbosa torralbo
- María Luisa Marina alegre (vocal)
- José Carlos Diez masa (vocal)
- jacques Crommen (vocal)