Tesis doctoral de Cabrera Heredia Jorge Rubén
The growth arrest specific gene 1 (gas1) protein has been proposed to function during development as an inhibitor of growth and a mediator of cell death, and is also re-expressed in adult neurons during excitotoxic stimuli. here we demonstrate that the gas1 protein shows high structural similarity to the gdnf (glial cell-derived neurotrophic factor) family receptors alpha, which mediate gdnf responses through the receptor tyrosine kinase ret. we found that gas1 binds ret in a ligand-independent manner and sequesters ret in lipid rafts. signalling downstream of ret is thus modified through a mechanism that involves the adaptor protein shc as well as erk2, eventually blocking akt activation. Consequently, when gas1 is induced, ret-mediated gdnf-dependent survival effects are compromised.
Datos académicos de la tesis doctoral «Identificación de los mecanismos moleculares que median la función de la proteína gas1 a través del receptor tirosina quinasa ret«
- Título de la tesis: Identificación de los mecanismos moleculares que median la función de la proteína gas1 a través del receptor tirosina quinasa ret
- Autor: Cabrera Heredia Jorge Rubén
- Universidad: Autónoma de Madrid
- Fecha de lectura de la tesis: 15/06/2006
Dirección y tribunal
- Director de la tesis
- Britt MellstrÁ¶m
- Tribunal
- Presidente del tribunal: joan xavier Comella carnice
- Francisco Wandosell (vocal)
- valentín Ceña (vocal)
- mario Encinas (vocal)