Tesis doctoral de Anna Company Casadevall
Oxygen activation in biological systems serves as inspiration for the development of alternatives to traditional oxidants which are considered highly toxic and environmentally harmful. In this work, synthetic compounds are used as models of the active site of dinuclear copper proteins and mononuclear non-heme iron systems involved in oxygen activation in natural systems. The prepared dinuclear copper complexes show the formation of copper(iii)-bis(oxo) species capable of performing the ortho-hydroxylation of phenols analogously to the reaction performed by tyrosinase. On the other hand, the synthesized iron systems can be considered as models of rieske dioxygenases and they can perform the estereospecific hydroxylation of alkanes and the epoxidation and cis-dihydroxylation of olefins using hydrogen peroxide as the oxidant. Overall, the work presented here demonstrates that the development of model systems constitutes a good approach for the study of natural systems.
Datos académicos de la tesis doctoral «O2 activation at bioinspired complexes: dinuclear copper systems and mononuclear non-heme iron compounds. mechanisms and catalytic applications in oxidative transformations.«
- Título de la tesis: O2 activation at bioinspired complexes: dinuclear copper systems and mononuclear non-heme iron compounds. mechanisms and catalytic applications in oxidative transformations.
- Autor: Anna Company Casadevall
- Universidad: Girona
- Fecha de lectura de la tesis: 16/12/2008
Dirección y tribunal
- Director de la tesis
- Miquel Costas Salgueiro
- Tribunal
- Presidente del tribunal: joaquin Borras tortonda
- agusti Lledos falco (vocal)
- pedro José Pérez romero (vocal)
- corinna Hess (vocal)