Tesis doctoral de Marta Portela Esteban
During cell life, cells accumulate mutations that can change their fitness.%&/Cell competition is a phenomenon that occurs among cells with different%&/metabolic rates. Cells with a proliferative advantage (winners) induce apoptosis%&/in loser cells and then displace them. Cell competition prevents the%&/accumulation of less fit cells and maintains cell number unchanged in tissues.%&/Field cancerization does not imply morphological alterations and seems to be%&/related with cell competition.%&/We have identified the drosophila dsparc as an early marker%&/upregulated in loser cells. Dsparc provides a transient shielding against cell-tocell%&/differences in cellular fitness, by setting a higher threshold for caspase%&/activation in loser cells. This mechanism may allow useful cells to recover from%&/transient and limited damage before they are unnecessarily eliminated by the%&/winners. If the differences in cellular fitness persist, cell competition induced%&/apoptosis is nevertheless triggered. Dsparc expression might have a function in%&/restoring homeostasis in damaged tissues. Our models of cell competition%&/based in dmyc expression or stress allow us to study de function of dsparc in%&/cell competition.%&/Human homologue of dsparc has a variable expression in many tumors,%&/promoting tumour development, metastasis and field cancerization, in the other%&/hand, human dsparc also can act as a tumour suppressor. The reason of these%&/opposite functions remains unsolved. So, our work in drosophila dsparc could%&/help to understand the dsparc role in human tumors.
Datos académicos de la tesis doctoral «Dsparc protege a las células de la eliminación por competición celular en drosophila melanogaster«
- Título de la tesis: Dsparc protege a las células de la eliminación por competición celular en drosophila melanogaster
- Autor: Marta Portela Esteban
- Universidad: Autónoma de Madrid
- Fecha de lectura de la tesis: 05/11/2010
Dirección y tribunal
- Director de la tesis
- Eduardo Moreno Lampaya
- Tribunal
- Presidente del tribunal: sonsoles Campuzano corrales
- enrique Martín blanco (vocal)
- pedro pablo López casas (vocal)
- florenci Serras rigalt (vocal)